新产品编号:770943

Chemical Name: (-)-2(R,S)-Methyloctanoic acid (2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3-yl ester; (-)-3-O-[2(R,S)-Methyloctanoyl]epigallocatechin
CAS No. 299462-48-9
项目整合开发状态: Preclinical
项目研究机构: Mitsui Norin (Originator)
合成路线:The dilithium anion of octanoic acid (I) was alkylated with iodomethane in the presence of HMPA to afford 2-methyloctanoic acid (II).After conversion of (II) to the corresponding acid chloride (III),condensation with (-)-epigallocatechin (IV) using trifluoroacetic acid as the catalyst furnished the title 3-O-acyl epigallocatechin.
📌 参考资料/链接:
参考文献标题:Antitumor promoting activities of 3-O-acyl-(-)-epigallocatechins
文献作者:Uesato,S.; Kitagawa,Y.; Hara,Y.; Tokuda,H.; Okuda,M.; Mou,X.Y.; Mukainaka,T.; Nishino,H.
参考来源:Bioorg Med Chem Lett 2000,10(15),1673