PNU-142796

Chemical Name: N-(4-Chlorobenzyl)-8-hydroxyquinoline-7-carboxamide
CAS No. 205037-64-5
项目整合开发状态: Biological Testing
项目研究机构: Pfizer (Originator)
合成路线:Treatment of 8-Hydroxyquinoline (I) with K2CO3 at high pressure and temperature yields carboxylic acid (II) which is coupled to amine (III) in xylenes by means of PCl3.Alternatively EDC稨Cl and HOBt稨2O are used for the coupling of (II) with (III) for the obtention of the desired product.