BBL22
Chemical Name: 9-Chloro-7-(2-fluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-amine
CAS No. 76988-22-2, 76988-23-3 (diHCl)
项目整合开发状态: Preclinical
项目研究机构: Bessor and Bessor Laboratories (Originator), University of Miami (Originator)
合成路线:The known benzazepinone (I) was reacted with dimethylformamide dimethylacetal in DMF to furnish enamino ketone (II).Subsequent cyclization of (II) with guanidine in the presence of sodium methoxide produced the title pyrimido-benzazepine.
📌 参考资料/链接：
参考文献标题:2-Benzazepines.5.Synthesis of pyrimido[5,4-d][2] benzazepines and their evaluation as anxiolytic agents
文献作者:Trybulski,E.J.; Benjamin,L.E.Sr.; Earley,J.V.; Fryer,R.I.; Gilman,N.W.; Reeder,E.; Walser,A.; Davidson,A.B.; Horst,W.D.; Sepinwall,J.; et al.
参考来源:J Med Chem 1983,26(11),1589