新产品编号:139725
Chemical Name: 9-Benzyl-2-chloro-6-(2-furyl)-9H-purine
CAS No. 176515-43-8
项目整合开发状态: Preclinical
项目研究机构: Universitetet i Oslo (Originator)
合成路线:2,6-Dichloropurine (I) was N-alkylated with benzyl chloride to give a 7:3 mixture of 9-benzyl-2,6-dichloropurine (II) and the 7-benzylated isomer (III).After chromatographic isolation of the desired 9-benzyl purine (II),Stille coupling with the 2-furyltin reagent (IV) in the presence of palladium catalyst furnished the corresponding 6-furylpurine.
📌 参考资料/链接：
参考文献标题:9-Benzylpurines with inhibitory activity against Mycobacterium tuberculosis
文献作者:Bakkestuen,A.K.; Gundersen,L.-L.; Langli,F.; Nolsoe,J.M.J.
参考来源:Bioorg Med Chem Lett 2000,10(11),1207
📄 详细内容
合成路线:2,6-Dichloropurine (I) was N-alkylated with benzyl chloride to give a 7:3 mixture of 9-benzyl-2,6-dichloropurine (II) and the 7-benzylated isomer (III).After chromatographic isolation of the desired 9-benzyl purine (II),Stille coupling with the 2-furyltin reagent (IV) in the presence of palladium catalyst furnished the corresponding 6-furylpurine.
参考文献标题:Regiochemistry in Stille couplings of 2,6-dihalopurines
文献作者:Langli,G.; et al.
参考来源:Tetrahedron 1996,52(15),5625
合成路线:2,6-Dichloropurine (I) was N-alkylated with benzyl chloride to give a 7:3 mixture of 9-benzyl-2,6-dichloropurine (II) and the 7-benzylated isomer (III).After chromatographic isolation of the desired 9-benzyl purine (II),Stille coupling with the 2-furyltin reagent (IV) in the presence of palladium catalyst furnished the corresponding 6-furylpurine.
参考文献标题:Synthesis and antimycobacterial activity of 6-arylpurines: The requirements for the N-9 substituent in active antimycobacterial purines
文献作者:Gundersen,L.-L.; Nissen-Meyer,J.; Spilsberg,B.
参考来源:J Med Chem 2002,45(6),1383