新产品编号:763033

Chemical Name: 4-[4-(4-Fluorophenyl)-5-(4-pyridyl)oxazol-2-yl]-1-methylpiperidin-4-ol
CAS No. 290357-24-3
项目整合开发状态: Preclinical
项目研究机构: Novartis (Originator)
合成路线:1-(4-Fluorophenyl)-2-(4-pyridyl)ethanone (I) was brominated in HOAc to yield bromoketone (II).Reaction of (II) with ammonium oxalate in formamide at 200 C produced a 1:1 mixture of imidazole (III) and oxazole (IV).After isolation of the desired oxazole (IV),its lithiation with n-butyllithium followed by addition to N-methyl-4-piperidinone (V) furnished the corresponding carbinol .