新产品编号:761451

Chemical Name: 5,5'-[(2,6-Dichlorophenyl)methylene]bis[4-hydroxy-2-(4-morpholinyl)-6-oxo-1,6-dihydropyridine-3-carboxylic acid] diethyl ester]
CAS No. 289896-25-9
项目整合开发状态: Preclinical
项目研究机构: Universit?degli Studi di Cagliari (Originator)
合成路线:Cyclization of the diaminoacrylate (I) with bis(2,4,6-trichlorophenyl) malonate (II) in hot toluene produced pyridone (III).This was then condensed with 2,6-dichlorobenzaldehyde (IV) in the presence of piperidine in refluxing EtOH to furnish the title bis-pyridyl derivative.
📌 参考资料/链接:
参考文献标题:Synthesis and antitumor activity of 4-hydroxy-2-pyridone derivatives
文献作者:Cocco,M.T.; Congiu,C.; Onnis,V.
参考来源:Eur J Med Chem 2000,35(5),545