NNC-26-1167

Chemical Name: 1-[N-[5-Amino-5-methyl-2(E)-hexenoyl]-N-methyl-3-(2-naphthyl)-D-alanyl-N-methyl-3-(2-thienyl)-D-alanyl]-1,2,2-trimethylhydrazine
CAS No. 232614-78-7
项目整合开发状态: Preclinical
项目研究机构: Novo Nordisk (Originator)
合成路线:The title compound was prepared by stepwise peptide synthesis starting from N-Fmoc-N-methyl-D-thienylalanine (I),which was condensed with trimethyl hydrazine (II) to give hydrazide (III).Removal of the Fmoc protecting group with piperidine in DMF provided amine (IV),which was subsequently coupled with N-methyl-D-naphthylalanine (V) in the presence of EDC and HOAt to furnish the dipeptide hydrazide (VI).After removal of the Fmoc group of (VI) with piperidine,the resulting amine (VII) was coupled with N-Boc-5-amino-5-methylhex-2-enoic acid (VIII),yielding amide (IX).Final deprotection of the Boc group of (IX) using trifluoroacetic acid afforded the title compound.