新产品编号:527315
Chemical Name: 1-[5-[2-[N-[4-(Acetamidosulfonyl)phenyl]carbamoyl]phenylsulfanyl]-5-oxopentyl]pyridinium bromide
CAS No. 221120-25-8
项目整合开发状态: Biological Testing
项目研究机构: Achillion (Originator), National Institutes of Health (Originator)
合成路线:Condensation of 2,2?dithiodibenzoyl chloride (I) with sulfacetamide (II) in pyridine afforded diamide (III).Reductive celavage of the disulfide bond of (III) by means of tris(2-carboxyethyl)phosphine produced the corresponding thiol (IV),which was subsequently acylated with 5-bromovaleryl chloride (V) yielding thioester (VI).Finally,displacement of the bromide with pyridine furnished the title pyridinium salt.
📌 参考资料/链接：
参考文献标题:Novel thiolesters and uses thereof
文献作者:Song,Y.; Turpin,J.A.; Huang,M.; Inman,J.K.; Walqvist,A.; Appella,E.; Maynard,A.; Rice,W.G.; Covell,D.G.(US Department of Health & Human Services)
参考来源:WO 9965871
📄 详细内容
合成路线:Condensation of 2,2?dithiodibenzoyl chloride (I) with sulfacetamide (II) in pyridine afforded diamide (III).Reductive celavage of the disulfide bond of (III) by means of tris(2-carboxyethyl)phosphine produced the corresponding thiol (IV),which was subsequently acylated with 5-bromovaleryl chloride (V) yielding thioester (VI).Finally,displacement of the bromide with pyridine furnished the title pyridinium salt.
参考文献标题:Synthesis and biological properties of novel pyridinioalkanoyl thiolesters (PATE) as anti-HIV-1 agents that target the viral nucleocapsid protein zinc fingers
文献作者:Turpin,J.A.; Song,Y.; Inman,J.K.; Huang,M.; Wallqvist,A.; Maynard,A.; Covell,D.G.; Rice,W.G.; Appella,E.
参考来源:J Med Chem 1999,42(1),67