SLV-310
Chemical Name: 2-[4-[4-(5-Fluoro-1H-indol-3-yl)-1,2,3,6-tetrahydropyridin-1-yl]butyl]-2,3-dihydro-1H-isoindole-1,3-dione hydrochloride; N-[4-[4-(5-Fluoro-1H-indol-3-yl)-1,2,3,6-tetrahydropyridin-1-yl]butyl]phthalimide hydrochloride
CAS No. 264869-71-8 (free base), 264869-69-4 (monohydrochloride)
项目整合开发状态: Phase II
项目研究机构: Solvay (Originator), Wyeth Pharmaceuticals (Codevelopment)
合成路线:Condensation of 5-fluoroindole (I) with 4-piperidone hydrate (II) under alkaline conditions leads to 5-fluoro-3-(1,2,3,6-tetrahydropyridin-4-yl)indole (III) (1,2).Subsequent alkylation of (III) with N-(4-bromobutyl)phthalimide (IV) furnishes the title compound (1-3).
📌 参考资料/链接：
参考文献标题:3-Tetrahydropyridin-4-yl indoles for treatment of psychotic disorders
文献作者:Kruse,C.G.; Tulp,M.T.M.; Van Hes,R.; Visser,G.M.; Van der Heijden,J.A.M.; Van Vliet,B.; Tipker,J.(Duphar International Research BV)
参考来源:EP 1121356; JP 2002527515; US 6391896; WO 0023441
📄 详细内容
合成路线:Condensation of 5-fluoroindole (I) with 4-piperidone hydrate (II) under alkaline conditions leads to 5-fluoro-3-(1,2,3,6-tetrahydropyridin-4-yl)indole (III) (1,2).Subsequent alkylation of (III) with N-(4-bromobutyl)phthalimide (IV) furnishes the title compound (1-3).
参考文献标题:Method of treating psychotic disorders
文献作者:Kruse,C.G.; Van Hes,R.; Long,S.K.; Van der Heijden,J.A.M.(Solvay Pharmaceuticals BV)
参考来源:WO 0069424
合成路线:Condensation of 5-fluoroindole (I) with 4-piperidone hydrate (II) under alkaline conditions leads to 5-fluoro-3-(1,2,3,6-tetrahydropyridin-4-yl)indole (III) (1,2).Subsequent alkylation of (III) with N-(4-bromobutyl)phthalimide (IV) furnishes the title compound (1-3).
参考文献标题:SLV310,a novel,potential antipsychotic,combining potent dopamine D2 receptor antagonism with serotonin reuptake inhibition
文献作者:Van Hes,R.; Smid,P.; Stroomer,C.N.J.; Tipker,K.; Tulp,M.T.M.; Van der Heyden,J.A.M.; McCreary,A.C.; Hesselink,M.B.; Kruse,C.G.
参考来源:Bioorg Med Chem Lett 2003,13(3),405
产品链接: CAS No. 264869-71-8››