新产品编号:68535
Chemical Name: 1,3,5-Trihexyl-2,4,6-triiodobenzene
CAS No. 155802-08-7
项目整合开发状态: Preclinical
项目研究机构: Amersham (Originator)
合成路线:Coupling of 1,3,5-trichlorobenzene (I) with n-hexylmagnesium bromide (II) produced the corresponding trihexylbenzene (III) (1-3).The title triiodo derivative was then obtained by iodination of (III) with either bis(trifluoroacetoxy)iodobenzene and iodine in CCl4 (1-3) or N-iodosuccinimide in the presence of trifluoromethanesulfonic acid.
📌 参考资料/链接：
参考文献标题:Compsns.of alkylbenzenes in film-forming materials for visualization of the gastrointestinal tract
文献作者:Josef,K.A.; Douty,B.D.; Bacon,E.R.; Illig,C.; Estep,K.G.(Sterling Winthrop Inc.)
参考来源:EP 0609589; JP 1994234664; US 5334370
📄 详细内容
合成路线:Coupling of 1,3,5-trichlorobenzene (I) with n-hexylmagnesium bromide (II) produced the corresponding trihexylbenzene (III) (1-3).The title triiodo derivative was then obtained by iodination of (III) with either bis(trifluoroacetoxy)iodobenzene and iodine in CCl4 (1-3) or N-iodosuccinimide in the presence of trifluoromethanesulfonic acid.
参考文献标题:Compsns.of alkylbenzenes and cellulose derivs.for visualization of the gastrointestinal tract
文献作者:Josef,K.A.; Bacon,E.R.; Estep,K.G.; Baker,E.J.; Toner,J.L.; Illig,C.R.; Douty,B.D.; Lee,R.W.(Sterling Winthrop Inc.)
参考来源:US 5385721
合成路线:Coupling of 1,3,5-trichlorobenzene (I) with n-hexylmagnesium bromide (II) produced the corresponding trihexylbenzene (III) (1-3).The title triiodo derivative was then obtained by iodination of (III) with either bis(trifluoroacetoxy)iodobenzene and iodine in CCl4 (1-3) or N-iodosuccinimide in the presence of trifluoromethanesulfonic acid.
参考文献标题:1,3,5-Trialkyl-2,4,6-triiodobenzenes: Novel X-ray contrast agents for gastrointestinal imaging
文献作者:Estep,K.G.; Josef,K.A.; Bacon,E.R.; Illig,C.R.; Toner,J.L.; Mishra,D.; Blazak,W.F.; Miller,D.M.; Johnson,D.K.; Allen,J.M.; Spencer,A.; Wilson,S.A.
参考来源:J Med Chem 2000,43(10),1940