DY-9804
Chemical Name: 4(R)-[(1R,6S)-4-(2-Chlorobenzyl)-5-oxo-3,4-diazabicyclo[4.1.0]hept-2-en-2-yloxy]-3(S)-hydroxy-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-6-carbonitrile
CAS No. 154186-97-7 (non-specified. stereoch.)
项目整合开发状态: Preclinical
项目研究机构: Daiichi Pharmaceutical (Originator)
合成路线:Condensation of 1,2-cyclo-propanedicarboxylic anhydride (I) with chlorobenzylhydrazine derivative (II) in EtOH (1) or acetonitrile affords derivative (III),which then reacts with epoxy-benzopyrancarbonitrile derivative (IV) in the presence of pyridine in EtOH to yield a mixture of two diastereomers (Va-b),from which the desired product is chromatographically separated.
📌 参考资料/链接：
参考文献标题:Diazabicycloalkene derivs.
文献作者:Mimura,T.; Kubo,H.(Daiichi Pharmaceutical Co.,Ltd.)
参考来源:EP 0571822; JP 1994025233; US 5418232
📄 详细内容
合成路线:Condensation of 1,2-cyclo-propanedicarboxylic anhydride (I) with chlorobenzylhydrazine derivative (II) in EtOH (1) or acetonitrile affords derivative (III),which then reacts with epoxy-benzopyrancarbonitrile derivative (IV) in the presence of pyridine in EtOH to yield a mixture of two diastereomers (Va-b),from which the desired product is chromatographically separated.
参考文献标题:Novel potassium channel opener prodrugs with a slow onset and prolonged duration of action
文献作者:Horino,H.; Mimura,T.; Kobayashi,S.; Ohta,M.; Kubo,H.; Ito,K.; Tsumura,M.; Kitagawa,M.
参考来源:Chem Pharm Bull 2000,48(4),490
产品链接: CAS No. 154186-97-7››