新产品编号:369115

Chemical Name: 1-[5'-O-[Hydroxy(tetradecyloxy)phosphoryl]-beta-D-arabinofuranosyl]-2-thiocytosine sodium salt
CAS No. 205826-63-7 (free acid), 205826-62-6 (Li salt)
项目整合开发状态: Preclinical
项目研究机构: Toagosei (Originator)
合成路线:The condensation of 1-(beta-D-arabinofuranosyl)-2-thiocytosine (I) with phosphoryl chloride gave intermediate (II).Acid chloride (II) was then condensed with myristyl alcohol (III) to furnish the desired phosphate ester,which was finally converted to the title sodium salt by treatment with aqueous NaOH.
📌 参考资料/链接:
参考文献标题:Enzymatic reactivity and anti-tumor activity of 1-(beta-D-arabinofuranosyl)-2-thiocytosine derivatives
文献作者:Kawaguchi,T.; Ichikawa,T.; Hasegawa,T.; Saneyoshi,M.; Wakayama,T.; Kato,H.; Yukita,A.; Nagata,T.
参考来源:Chem Pharm Bull 2000,48(4),454