新产品编号:729811

Chemical Name: 2-[4-[8-Hydroxy-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-3-yl]butyl]-2-[3-(trifluoromethyl)benzyl]malonic acid triethylamine salt hydrate
CAS No. 273224-16-1 (anhydrous), 273224-15-0 (anhydrous free acid)
项目整合开发状态: Biological Testing
项目研究机构: Metabasis (Originator)
合成路线:Dibenzyl malonate (I) was alkylated with 3-(trifluoromethyl)benzyl bromide (II) in the presence of Na in DMF to yield the 3-(trifluoromethyl)benzylmalonate (III).Further alkylation of (III) with 1,4-dibromobutane (IV) provided the bromobutyl derivative (V).Condensation of the known 6,7-dihydroimidazo[4,5-d][1,3]diazepin-8-one (VI) with bromide (V) in the presence of NaH and NaI furnished adduct (VII).The keto group of (VII) was then reduced to alcohol (VIII) employing NaBH4 in MeOH-CH2Cl2.Finally,hydrogenolysis of the benzyl ester groups of (VIII) in the presence of Pd/C and Et3N afforded the title dicarboxylate triethylammonium salt.