alpha-TEA
Chemical Name: 2-[2(R),5,7,8-Tetramethyl-2-[4(R),8(R),12-trimethyltridecyl]-3,4-dihydro-2H-1-benzopyran-6-yloxy]acetic acid
CAS No. 261929-52-6, 261929-63-9 (undefined isomer)
项目整合开发状态: Preclinical
项目研究机构: Research Development Foundation (Originator)
合成路线:Alkylation of R,R,R-alpha-tocopherol (I) with methyl bromoacetate in the presence of NaOH in DMF takes place with simultaneous hydrolysis of the methyl ester function to furnish the title carboxylic acid.
📌 参考资料/链接：
参考文献标题:Tocopherols,tocotrienols,other chroman and side chain derivs.and uses thereof
文献作者:Liu,S.; Kline,K.; Sanders,B.G.; Hurley,L.; Gardner,R.; Menchaca,M.; Yu,W.; Ramanan,P.N.; Israel,K.(Research Development Foundation )
参考来源:EP 1115398; JP 2002526446; US 6417223; WO 0016772
📄 详细内容
合成路线:Alkylation of R,R,R-alpha-tocopherol (I) with methyl bromoacetate in the presence of NaOH in DMF takes place with simultaneous hydrolysis of the methyl ester function to furnish the title carboxylic acid.
参考文献标题:Tocopherols,tocotrienols,other chroman and side chain derivs.and uses thereof
文献作者:Liu,S.; Kline,K.; Sanders,R.G.; Hurley,L.; Gardner,R.; Menchaca,M.; Yu,W.; Ramanan,P.N.; Israel,K.(Research Development Foundation )
参考来源:WO 0158889
合成路线:Alkylation of R,R,R-alpha-tocopherol (I) with methyl bromoacetate in the presence of NaOH in DMF takes place with simultaneous hydrolysis of the methyl ester function to furnish the title carboxylic acid.
参考文献标题:Tocopherols,tocotrienols,other chroman and side chain derivs.and uses thereof
文献作者:Kline,K.; Sanders,B.G.; Yu,W.(Research Development Foundation )
参考来源:US 2002107207; US 6703384
产品链接: CAS No. 261929-52-6››