N-89
Chemical Name: 1,2,6,7-Tetraoxaspiro[7.11]nonadecane
CAS No. 229323-98-2
项目整合开发状态: Preclinical
项目研究机构: Okayama University (Originator), Osaka University (Originator)
合成路线:Bishydroperoxide (III) was prepared by treatment of cyclododecanone (I) with hydrogen peroxide in formic acid or,alternatively,by ozonolysis of vinyl ether (II) in the presence of hydrogen peroxide at -70 C.Alkylation of bishydroperoxide (III) with 1,3-diiodopropane (IV) and CsOH in DMF furnished the title spirotetraoxane.
📌 参考资料/链接：
参考文献标题:Synthesis,crystal structure and anti-malarial activity of novel spiro-1,2,4,5-tetraoxacycloalkanes
文献作者:Tsuchiya,K.; et al.
参考来源:Tetrahedron Lett 1999,40(21),4077