SB-238039

Chemical Name: N-[4-[4-(4-Fluorophenyl)-1-(4-piperidinyl)-1H-imidazol-5-yl]pyridin-2-yl]-N-phenylamine
CAS No. 186315-03-7
项目整合开发状态: Preclinical
项目研究机构: GlaxoSmithKline (Originator)
合成路线:2-Chloronicotinic acid (I) was reduced to alcohol (II) employing borane,generated from NaBH4 and BF3.Et2O.Subsequent oxidation of (II) with N-bromosuccinimide produced aldehyde (III),which was condensed with N-Boc-4-aminopiperidine (IV),yielding imine (V).Addition to (V) of (4-fluorophenyl)-toluenesulfonylmethyl isocyanide (VI) gave rise to imidazole (VII).Then,displacement of the 2-chloro of (VII) by means of aniline (VIII) in the presence of NaH furnished the 2-anilinopyridine derivative (IX).The Boc protecting group of (IX) was finally removed by treatment with trifluoroacetic acid.