MLD-987, SDZ-MLD-987

Chemical Name: (1R,9S,12S(1'R,3'R,4'R),13R,14S,17R,21S,23S,24R,25S,27R)-17-Allyl-1,14-dihydroxy-23,25-dimethoxy-12-[2-[3-methoxy-4-[N-[4-(2-methoxy-2-oxoethyl)phenyl]carbamoyloxy]cyclohexyl]-1(E)-methylvinyl]-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0(4,9)]octacos-18(E)-ene-2,3,10,16-tetraone ; [3S-[3R*[E(1S*,2S*,4S*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]-4-[[[[4-[2-[1,4,5,6,7,8,11,12,13,14,15,16,17,18,19,20,21,23,24,25,26,26a-Docosahydro-5,19-dihydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-1,7,20,21-tetraoxo-8-(2-propenyl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosin-3-yl]-1-propenyl]-2-methoxycyclohexyl]oxy]carbonyl]amino]benzeneacetic acid methyl ester
CAS No. 183473-57-6
项目整合开发状态: Preclinical
项目研究机构: Novartis (Originator)
合成路线:The title carbamate was prepared by treatment of the ascomycin derivative (I) with triphosgene and dimethylaminopyridine at -77 C,followed by condensation of the intermediate chloroformate (II) with methyl 4-aminophenylacetate (III).