新产品编号:310581
Chemical Name: 4(S)-Ethyl-4,9-dihydroxy-12-(2,2,2-trifluoroethoxy)-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; 10-Hydroxy-5-(2,2,2-trifluoroethoxy)-20(S)-camptothecin
CAS No. 200619-14-3
项目整合开发状态: Preclinical
项目研究机构: Dr. Reddy's Research Foundation (Originator)
合成路线:Treatment of 10-hydroxycamptothecin (I) with EtOH and H2SO4 in the presence of FeCl3 produced 5-ethoxy-10-hydroxycamptothecin (II) along with minor amounts of the 5-hydroxy derivative (III).Hydrolysis of (II) to give (III) was effected using HCl in H2O-EtOH.Finally,acid-catalyzed condensation of (III) with 2,2,2-trifluoroethanol furnished the title compound.
📌 参考资料/链接：
参考文献标题:Short oligonucleotides for the inhibition of VEGF expression
文献作者:Bitonti,A.; Woessner,R.; Peyman,A.; Uhlmann,E.(Aventis Pharma Deutschland GmbH)
参考来源:EP 0979869; WO 0008141
📄 详细内容
合成路线:Treatment of 10-hydroxycamptothecin (I) with EtOH and H2SO4 in the presence of FeCl3 produced 5-ethoxy-10-hydroxycamptothecin (II) along with minor amounts of the 5-hydroxy derivative (III).Hydrolysis of (II) to give (III) was effected using HCl in H2O-EtOH.Finally,acid-catalyzed condensation of (III) with 2,2,2-trifluoroethanol furnished the title compound.
参考文献标题:Novel C-ring analogues of 20(S)-camptothecin.Part 3: Synthesis and their in vitro cytotoxicity of A-,B- and C-ring analogues
文献作者:Subrahmanyam,D.; Sarma,V.M.; Venkateswarlu,A.; Sastry,T.V.; Srinivas,A.S.; Krishna,C.V.; Deevi,D.S.; Kumar,S.A.; Babu,M.J.; Damodaran,N.K.
参考来源:Bioorg Med Chem Lett 2000,10(4),369