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项目整合精选>>>Strontium ranelate, Ranelic acid distrontium salt, FK-481, S-12911-2, S-12911, Osseor, Protelos, Protos
Strontium ranelate, Ranelic acid distrontium salt, FK-481, S-12911-2, S-12911, Osseor, Protelos, Protos
雷尼酸锶 5-[二(羧甲基)氨基]-2-羧基-4-氰基-3-噻吩乙酸 Chemical Name: 2-[2-Carboxy-4-cyano-5-[N,N-di(carboxymethyl)amino]thiophen-3-yl]acetic acid distrontium salt
CAS No. 135459-87-9, 135459-90-4 (free acid)
项目整合开发状态: Registered-2004
项目研究机构: Servier (Originator), Fujisawa (Licensee)
合成路线:Condensation of substituted aminothiophene (I) with ethyl bromoacetate (II) by means of K2CO3 in refluxing acetone furnishes the corresponding ethyl tetraester (III) (1),which can be converted into the desired strontium salt by treatment with NaOH in refluxing EtOH /H2O,followed by reaction with strontium hydroxide or strontium chloride in H2O.Alternatively,this transformation can also be achieved by direct treatment of (III) with strontium hydroxide in H2O/EtOH.
📌 参考资料/链接：
参考文献标题:Bivalent metal salts of 2-N,N-di(carboxymethyl)amino,3-cyano,4-carboxymethyl,5-carboxy-thiophene-acid,process for their preparation and pharmaceutical compsns.containing them
文献作者:Wierzbicki,M.; Bonnet,J.; Brisset,M.; Tsouderos,Y.(ADIR et Cie.)
参考来源:AU 9162033; EP 0415850; FR 2651497; JP 1991169876; US 5128367
📄 详细内容
合成路线:Condensation of substituted aminothiophene (I) with ethyl bromoacetate (II) by means of K2CO3 in refluxing acetone furnishes the corresponding ethyl tetraester (III) (1),which can be converted into the desired strontium salt by treatment with NaOH in refluxing EtOH /H2O,followed by reaction with strontium hydroxide or strontium chloride in H2O.Alternatively,this transformation can also be achieved by direct treatment of (III) with strontium hydroxide in H2O/EtOH.
参考文献标题:Reactivity of 2-aminothiophenes.Application to the synthesis of some thieno[2,3-b]pyrroles
文献作者:Wierzbicki,M.; et al.
参考来源:Bull Soc Chim France 1975,7-8(Part 2),1786
产品链接: CAS No. 135459-87-9›› 产品链接: CAS No.135459-90-4››