新产品编号:713991
Chemical Name: N-[3-(1,2,3,4-Tetrahydroquinolin-1-ylsulfonyl)phenyl]-N,N-bis(1H-imidazol-5-ylmethyl)amine; 1-[3-[Bis(1H-imidazol-5-ylmethyl)amino]phenylsulfonyl]-1,2,3,4-tetrahydroquinoline
CAS No. 263845-08-5
项目整合开发状态: Biological Testing
项目研究机构: Bristol-Myers Squibb (Originator)
合成路线:Condensation of 3-nitrobenzenesulfonyl chloride (I) with tetrahydroquinoline (II) in the presence of pyridine gave sulfonamide (III).Reduction of the nitro group of (III) with stannous chloride produced the aniline derivative (IV).The title compound was then obtained by reductive alkylation of amine (IV) with 4-formylimidazole (V) using sodium triacetoxyborohydride as the reducing reagent.
📌 参考资料/链接：
参考文献标题:3-Imidazolylmethylaminophenylsulfonyltetrahydroquinolines,a novel series of farnesyltransferase inhibitors
文献作者:Ding,C.Z.; Hunt,J.T.; Ricca,C.; Manne,V.
参考来源:Bioorg Med Chem Lett 2000,10(3),273