AG-5507

Chemical Name: 4-(3,5-Dimethoxyphenyl)-13-[2-oxo-2-(3,4,5-trimethoxyphenyl)acetyl]-4,7,13-triazatricyclo[7.3.1.0(2,7)]tridec-2-ene-5,8-dione; 2-(3,5-Dimethoxyphenyl)-12-[2-oxo-2-(3,4,5-trimethoxyphenyl)acetyl]-8,9,10,11-tetrahydro-7,11-imino-2H-pyrazino[1,2-a]azocine-3,6(4H,7H)-dione
CAS No. 255910-54-4
项目整合开发状态: Biological Testing
项目研究机构: Agouron (Originator)
合成路线:Pyridine-2,6-dicarboxylic acid (I) was hydrogenated to the corresponding piperidine,which was subsequently protected as the N-benzyloxycarbonyl derivative (II).The dicarboxylic acid (II) was converted into the cyclic anhydride (III) upon heating with Ac2O.Anhydride (III) was then dissolved in MeOH to produce the mono ester (IV).The electrochemical oxidation of acid (IV) in methanol gave rise to the methoxypiperidine (V).The methoxy group of (V) was then displaced by allyl trimethylsilane (VI) in the presence of TiCl4 to furnish the allyl piperidine (VII),which was further oxidized to diol (VIII) employing OsO4 and N-methylmorpholine-N-oxide.Then,oxidative cleavage of diol (VIII) by means of NaIO4 gave aldehyde (IX).After aldehyde (IX) ketalization with trimethyl orthoformate,basic hydrolysis of the methyl ester group provided carboxylic acid (X).This was activated as the mixed anhydride with isobutyl chloroformate and then treated with ammonia to afford amide (XI).The cyclization of the ketal amide (XI) upon treatment with pyridinium p-toluenesulfonate gave rise to the bicyclic derivative (XII).Upon bromination of (XII) in the presence of NaOMe,the bicyclic compound (XII) rearranged to the ketal lactam (XIII).Alkylation of the lactam nitrogen of (XIII) with ethyl bromoacetate and NaH produced ester (XIV),which was then hydrolyzed to the carboxylic acid (XV).

合成路线:Carboxylic acid (XV) was coupled with cyclopentylamine (XVI) using EDC and HOBt to produce amide (XVII),which was cyclized to the fused pyrazinone derivative (XVIII) by treatment with pyridinium p-toluenesulfonate in toluene.The benzyloxycarbonyl group of (XVIII) was then removed by catalytic hydrogenation to give amine (XIX).This was finally coupled with (3,4,5-trimethoxyphenyl)glyoxylic acid (XX) to yield the title amide.

合成路线:Pyridine-2,6-dicarboxylic acid (I) was hydrogenated to the corresponding piperidine,which was subsequently protected as the N-benzyloxycarbonyl derivative (II).The dicarboxylic acid (II) was converted into the cyclic anhydride (III) upon heating with Ac2O.Anhydride (III) was then dissolved in MeOH to produce the mono ester (IV).The electrochemical oxidation of acid (IV) in methanol gave rise to the methoxypiperidine (V).The methoxy group of (V) was then displaced by allyl trimethylsilane (VI) in the presence of TiCl4 to furnish the allyl piperidine (VII),which was further oxidized to diol (VIII) employing OsO4 and N-methylmorpholine-N-oxide.Then,oxidative cleavage of diol (VIII) by means of NaIO4 gave aldehyde (IX).After aldehyde (IX) ketalization with trimethyl orthoformate,basic hydrolysis of the methyl ester group provided carboxylic acid (X).This was activated as the mixed anhydride with isobutyl chloroformate and then treated with ammonia to afford amide (XI).The cyclization of the ketal amide (XI) upon treatment with pyridinium p-toluenesulfonate gave rise to the bicyclic derivative (XII).Upon bromination of (XII) in the presence of NaOMe,the bicyclic compound (XII) rearranged to the ketal lactam (XIII).Alkylation of the lactam nitrogen of (XIII) with ethyl bromoacetate and NaH produced ester (XIV),which was then hydrolyzed to the carboxylic acid (XV).

合成路线:Carboxylic acid (XV) was coupled with 3,5-dimethoxyaniline (XVI) using EDC and HOBt to produce amide (XVII),which was cyclized to the fused pyrazinone derivative (XVIII) by treatment with pyridinium p-toluenesulfonate in toluene.The benzyloxycarbonyl group of (XVIII) was then removed by catalytic hydrogenation to give amine (XIX).This was finally coupled with (3,4,5-trimethoxyphenyl)glyoxylic acid (XX) to yield the title amide.