新产品编号:24239

Chemical Name: 4-[1-(3-Methyl-4-oxo-2-thioxothiazolidin-5-ylidenemethyl)naphthalen-2-yloxy]butyric acid
CAS No. 123021-26-1
项目整合开发状态: Preclinical
项目研究机构: Dainippon Pharmaceutical (Originator)
合成路线:Alkylation of 2-hydroxy-1-naphthaldehyde (I) with ethyl 4-bromobutyrate (II) in the presence of K2CO3 and tris[2-(2-methoxyethoxy)ethyl]amine furnished the naph-thoxybutyrate ester (III),which was hydrolyzed to the corresponding carboxylic acid (IV) using NaOH in aqueous dioxan.Condensation of (IV) with N-methyl rhodanine (V) by means of NaOAc in refluxing AcOH gave rise to the title compound.