L-708906
Chemical Name: 4-[3,5-Bis(benzyloxy)phenyl]-2,4-dioxobutyric acid
CAS No. 251963-74-3
项目整合开发状态: Preclinical
项目研究机构: Amgen (Originator), Merck & Co. (Originator)
合成路线:Claisen condensation of 3',5'-bis(benzyloxy)acetophenone (I) with dimethyl oxalate or diethyloxalate in the presence of NaH in refluxing DME yielded diketo ester (II).Basic hydrolysis of the methyl ester group of (I) then furnished the title carboxylic acid.
📌 参考资料/链接：
参考文献标题:HIV integrase inhibitors
文献作者:Guare,J.P.Jr.; Jaen,J.; Tran,L.; Vacca,J.P.; Zhuang,L.; Egbertson,M.; Medina,J.C.; Melamed,J.; Clark,D.L.; Fisher,T.E.; Langford,M.; Wai,J.S.; Payne,L.S.; Embrey,M.W.; Young,S.D.(Merck & Co.,Inc.; Tularik Inc.)
参考来源:WO 9962520
📄 详细内容
合成路线:Claisen condensation of 3',5'-bis(benzyloxy)acetophenone (I) with dimethyl oxalate or diethyloxalate in the presence of NaH in refluxing DME yielded diketo ester (II).Basic hydrolysis of the methyl ester group of (I) then furnished the title carboxylic acid.
参考文献标题:Structure activity of 3-aryl-1,3-diketo-containing compounds as HIV-1 integrase inhibitors
文献作者:Pais,G.C.G.; Zhang,X.; Marchand,C.; Neamati,N.; Cowansage,K.; Svarovskaia,E.S.; Pathak,V.K.; Tang,Y.; Nicklaus,M.; Pommier,Y.; Burke,T.R.Jr.
参考来源:J Med Chem 2002,45(15),3184
产品链接: CAS No. 251963-74-3››