HI-443
Chemical Name: N-(5-Bromopyridin-2-yl)-N'-[2-(2-thienyl)ethyl]thiourea
CAS No. 258340-15-7
项目整合开发状态: Preclinical
项目研究机构: Parker Hughes Institute (Originator)
合成路线:Reaction of 2-amino-5-bromopyridine (I) with thiocarbonyl diimidazole (II) provided the thioimidazolide (III).This was then coupled with 2-(2-thienyl)ethyl amine (IV) to furnish the target thiourea.
📌 参考资料/链接：
参考文献标题:Thiophene-ethyl thiourea cpds.and use
文献作者:Ventatachalam,T.K.; Uckun,F.M.(Parker Hughes Institute)
参考来源:US 6124324; WO 0078755
📄 详细内容
合成路线:Reaction of 2-amino-5-bromopyridine (I) with thiocarbonyl diimidazole (II) provided the thioimidazolide (III).This was then coupled with 2-(2-thienyl)ethyl amine (IV) to furnish the target thiourea.
参考文献标题:N'-[2-(2-Thiophene)ethyl]-N'-[2-(5-bromopyridyl)] thiourea as a potent inhibitor of NNI-resistant and multidrug-resistant human immunodeficiency virus-1
文献作者:Uckun,F.M.; Pendergrass,S.; Maher,D.; Zhu,D.; Tuel-Ahlgren,L.; Mao,C.; Venkatachalam,T.K.
参考来源:Bioorg Med Chem Lett 1999,9(24),3411
产品链接: CAS No. 258340-15-7››