LAV-694, SDZ-LAV-694

Chemical Name: 6-[2-(2,5-Dimethoxyphenyl)ethyl]-4-ethylquinazoline
CAS No. 182878-97-3
项目整合开发状态: Preclinical
项目研究机构: Novartis (Originator)
合成路线:Palladium-catalyzed coupling between 4-ethyl-6-iodoquinazoline (I) and (2,5-dimethoxyphenyl)acetylene (II) affords the diaryl acetylene (III).Subsequent catalytic hydrogenation of the triple bond of (III) in the presence of Pd/C gives rise to the target compound.