新产品编号:647547

Chemical Name: 2-[1-(2-Phenylethyl)piperidin-2-yl]acetic acid methyl ester
CAS No. 247259-34-3
项目整合开发状态: Preclinical
项目研究机构: Georgia Institute of Technology (Originator), Mercer University (Originator)
合成路线:2-Pyridyl acetic acid (I) is converted into its methyl ester derivative (II) by means of SOCl2 in MeOH and then vigorously hydrogenated over Pt in MeOH to afford 2-(2-piperidyl)acetic acid methyl (III).Finally,piperidine ester derivative (III) is alkylated on nitrogen with 2-phenylethylbromide (IV) in DMF in the presence of K2CO3.