新产品编号:535225
Chemical Name: 2-Ethoxy-3-[4-[2-(4-methyl-1-oxo-1,2-dihydro-2-phthalazinyl)ethoxy]phenyl]propionamide
CAS No. 221321-60-4
项目整合开发状态: Preclinical
项目研究机构: SSP (Originator)
合成路线:Debenzylation of propanamide (I) by means of H2 over Pd/C in EtOH/HOAc provides alcohol (II),which is then mesylated with methanesulfonyl chloride (MsCl) and Et3N in CH2Cl2 to yield derivative (III).Finally,coupling of (III) with quinazoline derivative (IV) by means of K2CO3 in DMF affords the desired compound.
📌 参考资料/链接：
参考文献标题:alpha-Substd.phenylpropionic acid deriv.and medicine containing the same
文献作者:Kotake,J.; Nagao,Y.; Konno,F.; Sato,S.; Honda,H.; Ishii,F.(SSP Co.,Ltd.)
参考来源:CA 2247772; EP 0903343; JP 1999158144
📄 详细内容
合成路线:Debenzylation of propanamide (I) by means of H2 over Pd/C in EtOH/HOAc provides alcohol (II),which is then mesylated with methanesulfonyl chloride (MsCl) and Et3N in CH2Cl2 to yield derivative (III).Finally,coupling of (III) with quinazoline derivative (IV) by means of K2CO3 in DMF affords the desired compound.
参考文献标题:Preparation of benzazine derivatives with hypoglycemic activity
文献作者:Ishii,F.; Koya,H.; Honda,H.; Nagao,Y.; Kotake,J.; Konno,F.; Sato,S.; Koda,T.; Ito,Y.
参考来源:19th Symp Med Chem (Nov 17 1999,Tokyo) 1999,Abst 1P-05