OT-7999

Chemical Name: 5-Butyl-8-[4-(trifluoromethyl)phenyl]-1H-[1,2,4]triazolo[5,1-i]purine
CAS No. 246031-23-2
项目整合开发状态: Preclinical
项目研究机构: Otsuka (Originator)
合成路线:The reaction of 4-amino-1H-imidazole-5-carbonitrile (I) with trimethyl orthopentanoate (II) in hot DMF gives methyl N-(5-cyano-1H-imidazol-4-yl)pentanoimidate (III),which is then cyclized with benzoic hydrazide (IV) in hot DMF to yield the target triazolo-purine derivative.