KF-58333

Chemical Name: (1aR,2Z,4E,6E,14R,15aR)-8-Chloro-9,11-dihydroxy-14-methyl-1a,14,15,15a-tetrahydro-6H-oxireno[e][2]benzoxacyclotetradecine-6,12(7H)-dione 6-[O-[2-(2-oxo-1-pyrrolidinyl)ethyl]oxime]; (3R,5R,6R,7Z,9E,11E)-13-Chloro-5,6-epoxy-4,16-dihydroxy-3-methyl-11-[2-(2-oxopyrrolidin-1-yl)ethoxyimino]-3,4,5,6,11,12-hexahydro-1H-2-benzoxacyclotetradecin-1-one
CAS No. 308244-21-5, 207745-74-2 (deleted CAS)
项目整合开发状态: Preclinical
项目研究机构: Kyowa Hakko (Originator), National Cancer Institute (Codevelopment)
合成路线:The title oxime derivative was prepared by reaction of the microbial metabolite radiciclol (I) with O-[2-(2-oxo-1-pyrrolidinyl)ethyl]hydroxylamine (II),followed by separation of the resulting mixture of E/Z isomers by preparative HPLC.