LY-314177
Chemical Name: 1(S),4a(S)-Dimethyl-6-methoxy-9-(4-methylpiperazin-1-ylimino)-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxylic acid methyl ester
CAS No. 199291-57-1 (beta-isomer)
项目整合开发状态: Preclinical
项目研究机构: Lilly (Originator)
合成路线:The oxidation of methyl O-methylpodocarpate (I) with chromium trioxide produced ketone (II).This was then condensed with 1-amino-4-methylpiperazine (III) to yield the title hydrazone.
📌 参考资料/链接：
参考文献标题:In vitro and in vivo activity of a series of influenza A inhibitors derived from podocarpic acid
文献作者:Sachs,R.K.; Hornback,W.J.; Tang,J.; Munroe,J.E.
参考来源:39th Intersci Conf Antimicrob Agents Chemother (Sept 26 1999,San Francisco) 1999,Abst F950