J-110441

Chemical Name: (1R,5S,6S)-2-(Benzothien-2-ylsulfanyl)-6-[1(R)-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylic acid sodium salt; (4R,5S,6S)-3-(1-benzothiophen-2-ylsulfanyl)-6-[1(R)-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid sodium salt
CAS No. 165817-65-2
项目整合开发状态: Biological Testing
项目研究机构: Banyu (Originator)
合成路线:Carbapenem-2-diphenylphosphate (I) was condensed with the sodium salt of 2-mercaptobenzothiophene (II) to give thioether (III).The p-nitrobenzyl group of (III) was then deprotected by hydrogenation over Pd/C in the presence of NaHCO3 to afford the corresponding carboxylic acid sodium salt.