ODG-PFA-OMe
Chemical Name: Hydroxy[2(R)-hydroxy-3-(octadecyloxy)propoxy]phosphorylcarboxylic acid methyl ester sodium salt
CAS No. 179390-99-9 (free acid)
项目整合开发状态: Preclinical
项目研究机构: University of California, Oakland (Originator)
合成路线:The title compound was prepared by coupling 1-O-octadecyl-sn-glycerol (I) with methyl phosphonoformate (II) in the presence of DCC in pyridine,followed by conversion to the monosodium salt by means of an aqueous solution of NaHCO3.
📌 参考资料/链接：
参考文献标题:Intravitreal toxicology and therapeutic efficacy of the carboxymethyl ester of the 1-O-octadecyl-sn-glycerol-3-phosphonoformate (ODG-PFA-O-Me),a novel lipid antiviral prodrug for intraocular drug delivery
文献作者:Avila,C.P.; Gardner,M.F.; Freeman,W.R.; Keef,K..S.; Bergeron-Lynn,G.; Cheng,L.Y.; Hostetler,K.Y.; Beadle,J.R.; Wiley,C.A.
参考来源:J Ocular Pharmacol Ther 1999,15(4),363