SoRI-9409
Chemical Name: 5'-(4-Chlorophenyl)-17-(cyclopropylmethyl)-6,7-didehydro-3,14-dihydroxy-4,5alpha-epoxypyrido[2',3':6,7]morphinan
CAS No. 248273-61-2
项目整合开发状态: Preclinical
项目研究机构: Southern Research Institute (Originator)
合成路线:The title compound was prepared by condensation of naltrexone hydrochloride (I) with 2-(4-chlorophenyl)malondialdehyde (II) in the presence of ammonium acetate in refluxing AcOH.
📌 参考资料/链接：
参考文献标题:Pyridomorphinans and use thereof
文献作者:Ananthan,S.(Southern Research Institute)
参考来源:WO 0112196
📄 详细内容
合成路线:The title compound was prepared by condensation of naltrexone hydrochloride (I) with 2-(4-chlorophenyl)malondialdehyde (II) in the presence of ammonium acetate in refluxing AcOH.
参考文献标题:Synthesis,opioid receptor binding,and biological activities of naltrexone-derived pyrido- and pyrimidomorphinans
文献作者:Ananthan,S.; Kezar,H.S.III; Carter,R.L.; Saini,S.K.; Rice,K.C.; Wells,J.L.; Davis,P.; Xu,H.; Dersch,C.M.; Bilsky,E.J.; Porreca,F.; Rothman,R.B.
参考来源:J Med Chem 1999,42(18),3527