SK-1899

Chemical Name: Acetic acid 4-(2-amino-9H-purin-9-yl)-2-(isopropoxycarbonyloxymethyl)butyl ester; 9-[4-(Acetoxy)-3-(isopropoxycarbonyloxymethyl)butyl]-2-aminopurine
CAS No. 247081-81-8
项目整合开发状态: Preclinical
项目研究机构: SK Chemicals (Originator)
合成路线:6-Deoxypenciclovir (I) was reacted with trimethyl orthoacetate in the presence of p-toluenesulfonic acid to give the cyclic orthoacetate intermediate (II) which,after aqueous quenching,afforded monoacetate ester (III).Subsequent treatment of (III) with isopropyl p-nitrophenyl carbonate (IV) using a catalytic amount of dimethylaminopyridine provided the target carbonate ester.