RTI-112
Chemical Name: (-)-(1R,2S,3S,5S)-(4-Chloro-3-methylphenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic acid methyl ester
CAS No. 143982-09-6, 150653-92-2 (HCl)
项目整合开发状态: Preclinical
项目研究机构: Research Triangle Institute (Originator)
合成路线:Conjugate addition of 4-chloro-3-methylphenylmagnesium iodide (II) to anhydroecgonine methyl ester (I) at -40 C,followed by quenching with trifluoroacetic acid at -78 C afforded a 1:1.6 mixture of 2alpha and 2beta-3-aryltropane-2-carboxylate esters (III).The target 2beta-isomer was then isolated by column chromatography.
📌 参考资料/链接：
参考文献标题:Synthesis,ligand binding,and QSAR (CoMFA and classical) study of 3beta-(3'-substituted phenyl)-,3beta-(4'-substituted phenyl)-,and 3beta-(3',4'-disubstituted phenyl)tropane-2beta-carboxylic acid methyl esters
文献作者:Lewin,A.H.; Carroll,F.I.; Abraham,P.; Mascarella,S.W.; Gao,Y.; Boja,J.W.; Kuhar,M.J.; Kuzemko,M.A.
参考来源:J Med Chem 1994,37(18),2865
📄 详细内容
合成路线:Conjugate addition of 4-chloro-3-methylphenylmagnesium iodide (II) to anhydroecgonine methyl ester (I) at -40 C,followed by quenching with trifluoroacetic acid at -78 C afforded a 1:1.6 mixture of 2alpha and 2beta-3-aryltropane-2-carboxylate esters (III).The target 2beta-isomer was then isolated by column chromatography.
参考文献标题:
文献作者:Suslu,I.; Altinoz,S.
参考来源:Med Chem Res 1992,1(6),382-387
产品链接: CAS No. 143982-09-6›› 产品链接: CAS No.150653-92-2››