Vinxaltine sulfate, Vinfosiltine sulfate, Servier-12363, S-12363
长春磷汀 Chemical Name: (1S)-1-[3-(O4-Deacetyl-3-demethoxycarbonylvincaleukoblastinyl)carbonylamino]-2-methylpropylphosphonic acid diethyl ester sulfate; [23(S)]-4-Deacetyl-3-de(methoxycarbonyl)-3-[(2-methyl-1-phosphonopropyl)carbamoyl]vincaleukoblastine diethyl ester sulfate
CAS No. 123286-01-1, 123286-00-0 (free base)
项目整合开发状态: Phase II
项目研究机构: Servier (Originator)
合成路线:The condensation of O4-deacetyl-vinblastine carboxazide (I) with diethyl ester (+) of 1-amino-2-methylpropylphosphonic acid (II),in cold methylene chloride,gives (1S)-1-[3-(O4-deacetyl-3-demethoxycarbonylvincaleukoblastinyl) carbonylamino]-2-methylpropylphosphonic acid diethyl ester (III).
📌 参考资料/链接：
参考文献标题:Vinfosiltine Sulfate
文献作者:Bizzari,J.P.
参考来源:Drugs Fut 1991,16(9),822
📄 详细内容
合成路线:The condensation of O4-deacetyl-vinblastine carboxazide (I) with diethyl ester (+) of 1-amino-2-methylpropylphosphonic acid (II),in cold methylene chloride,gives (1S)-1-[3-(O4-deacetyl-3-demethoxycarbonylvincaleukoblastinyl) carbonylamino]-2-methylpropylphosphonic acid diethyl ester (III).
参考文献标题:New alpha-aminophosphonic acid derivatives of vinblastine: Chemistry and antitumor activity
文献作者:Lavielle,G.; Hautefaye,P.; Schaeffer,C.; Boutin,J.A.; Cudennec,C.A.; Pierr? A.
参考来源:J Med Chem 1991,34(7),1998-2003
产品链接: CAS No.123286-00-0››