Vinzolidine sulfate, LY-104208

长春利定 Chemical Name: Methyl (3R,5S,7R,9S)-9-[3'-(2-chloroethyl)-6,7-didehydro-4beta-hydroxy-16-methoxy-1-methyl-2',4'-dioxo-2beta,3beta,5alpha,12beta,19alpha-spiro[aspidospermidine-3,5'oxazolidin]-15-yl]-5-ethyl-1,4,5,6,7,8,9,10-octahydro-5-hydroxy-2H-3,7-methanoazacycloundecino[5,4-b]indole-9-carboxylate 4'-acetate (ester) sulfate (1:1) (salt); [5S-(5R*,7S*,9S*)]-9-[(2beta,3beta,4beta,5alpha,12beta,19alpha)-4-(Acetyloxy)-3'-(2-chloroethyl)-6,7-didehydro-16-methoxy-1-methyl-2',4'-dioxospiro[aspidospermidine-3,5'-oxazolidin]-15-yl]-5-ethyl-1,4,5,6,7,8,9,10-octahydro-5-hydroxy-2H-3,7-methanoazacycloundecino[5,4-b]indole-9-carboxylic acid methyl ester sulfate (1:1) (salt)
CAS No. 67699-41-6, 67699-40-5 (free base)
项目整合开发状态: Phase II
项目研究机构: Lilly (Originator)
合成路线:The reaction of vinblastine (I) with 2-chloroethyl isocyanate (II) in refluxing benzene gives the corresponding N-(2-chloroethyl)carbamate (III),which is cyclized by continuous refluxing in the same solvent.