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项目整合精选>>>Manganese dipyridoxal diphosphate trisodium salt, Mangafodipir trisodium, Win-59010-2, S-095, MnDPDP, Teslascan
Manganese dipyridoxal diphosphate trisodium salt, Mangafodipir trisodium, Win-59010-2, S-095, MnDPDP, Teslascan
锰酸盐(6-),[[N,N'-1,2-乙二基铵[N-[[3-(羟基-kO)-2-甲基-5-[(磷酸氧)甲基]-4-吡啶基甲基]甘氨酸-kN,kO]](8-)]-, (OC-6-13)-(9CI) 锰福地吡Chemical Name: Trisodium trihydrogen (OC-6-13)-[[N,N'-1,2-ethanediylbis[N-[[3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]-4-pyridinyl]methyl]glycinato](8-)]manganate(6-)
CAS No. 140678-14-4, 118248-94-5 (anion), 155319-91-8 (free acid)
项目整合开发状态: Launched-1997
项目研究机构: Amersham (Originator), Amersham Health (Originator), Sanofi-Aventis (Licensee)
合成路线:The condensation of pyridoxal 5-phosphate (I) with ethylenediamine (II) in methanol by means of NaOH gives the corresponding diimine (III),which is reduced with hydrogen over Pt/C in methanol/water yielding the expected diamine (IV).The reaction of (IV) with bromoacetic acid (V) by means of NaOH in methanol/water affords the N,N'-diacetic acid derivative (VI),which is finally treated with MnCl2 in water containing NaOH.
📌 参考资料/链接：
参考文献标题:Mangafodipir Trisodium
文献作者:Graul,A.; Leeson,P.; Castar,J.
参考来源:Drugs Fut 1997,22(9),974
📄 详细内容
合成路线:The condensation of pyridoxal 5-phosphate (I) with ethylenediamine (II) in methanol by means of NaOH gives the corresponding diimine (III),which is reduced with hydrogen over Pt/C in methanol/water yielding the expected diamine (IV).The reaction of (IV) with bromoacetic acid (V) by means of NaOH in methanol/water affords the N,N'-diacetic acid derivative (VI),which is finally treated with MnCl2 in water containing NaOH.
参考文献标题:Manganese(II) N,N'-dipyridoxylethylenediamine-N,N'-diacetate 5,5'-bis(phosphate).Synthesis and characterization of a paramagnetic chelate for magnetic resonance imaging enhancement
文献作者:Rocklage,S.M.; Cacheris,W.P.; Quay,S.C.; Hahn,F.E.; Raymond,K.N.
参考来源:Inorg Chem 1989,28477-85