TA-5707
重氮基烯二羧酸,二乙基酯,自由基离子(1+)(9CI) Chemical Name: 6-Methyl-N-1H-tetrazol-5-yl-2-pyridinecarboxamide monosodium salt; N-(Tetrazolyl-5-yl)-6-methylpyridine-2-carboxamide monosodium salt
CAS No. 83282-09-1, 83282-08-0 (free acid)
项目整合开发状态: Phase II
项目研究机构: Tanabe Seiyaku (Originator)
合成路线:The reaction of 6-methylpyridine-2-carboxylic acid (I) with refluxing SOCl2 gives 6-methylpyridine-2-carbonyl chloride (II),which is condensed with 5-aminotetrazole (III) by means of triethylamine in hot DMF.
📌 参考资料/链接：
参考文献标题:TA-5707
文献作者:Serradell,M.N.; Castar,J.
参考来源:Drugs Fut 1984,9(7),527
📄 详细内容
合成路线:The reaction of 6-methylpyridine-2-carboxylic acid (I) with refluxing SOCl2 gives 6-methylpyridine-2-carbonyl chloride (II),which is condensed with 5-aminotetrazole (III) by means of triethylamine in hot DMF.
参考文献标题:Antiallergic agents.3.N-(1H-Tetrazol-5-yl)-2-pyridinecarboxamides
文献作者:Takeda,M.; Sekine,Y.; Ono,Y.; Hashiyama,T.; Honma,Y.; Tsuzurahara,K.; Hanamoto,K.
参考来源:J Med Chem 1984,27(2),125-128
合成路线:The reaction of 6-methylpyridine-2-carboxylic acid (I) with refluxing SOCl2 gives 6-methylpyridine-2-carbonyl chloride (II),which is condensed with 5-aminotetrazole (III) by means of triethylamine in hot DMF.
参考文献标题:2-Pyridinecarboxamide derivatives compositions containing same and method of using same
文献作者:Takeda,M.; Honma,Y.; Tsuzurahara,K.
参考来源:EP 0053789; ES 8303398; JP 1482289C; JP 57095984; US 4404214
产品链接: CAS No. 83282-09-1›› 产品链接: CAS No.83282-08-0››