NS-2381-[11C], [11C]-NS-2381

Chemical Name: 8-([11C]Methyl)-3-[4-(trifluoromethyl)phenyl]-8-azabicyclo[3.2.1]oct-2-ene
CAS No. 189746-51-8 (maleate), 189746-50-7 (unlabeled)
项目整合开发状态: Preclinical
项目研究机构: NeuroSearch (Originator)
合成路线:Lithiation of 4-bromobenzotrifluoride (I) by means of butyllithium provided the organolithium derivative (II),which was condensed with 8-methyl-8-azabicyclo[3.2.1]octan-3-one (III) to give the carbinol adduct (IV).Subsequent dehydration of (IV) employing HCl in AcOH produced the title olefin.