新产品编号:994005
Chemical Name: 4-[4-(4-Chlorophenyl)-1H-pyrazol-3-yl]morpholine
CAS No. 88743-53-7
项目整合开发状态: Preclinical
项目研究机构: Asta Medica (Originator)
合成路线:(4-Chlorophenyl)thioacetic acid morpholide (II) was prepared by Willgerodt-Kindler reaction of 4'-chloroacetophenone (I) with sulfur and morpholine.Subsequent condensation of (II) with triethyl orthoformate and morpholine provided the 3-(4-morpholinyl)thioacrylic acid morpholide (IIIa-b).Finally,ring closure of (IIIa-b) with hydrazine hydrochloride in refluxing EtOH furnished the title pyrazole.
📌 参考资料/链接：
参考文献标题:Synthesis,anticonvulsant activity,and structure-activity relationships of sodium channel blocking 3-aminopyrroles
文献作者:Unverferth,K.; Engel,J.; Hofgen,N.; Rostock,A.; Gunther,R.; Lankau,H.J.; Menzer,M.; Rolfs,A.; Liebscher,J.; Muller,B.; Hofmann,H.J.
参考来源:J Med Chem 1998,41(1),63