NCS-706
Chemical Name: 2-Iodo-9-(2-methoxybenzyl)-N6-methyladenine hydrochloride
CAS No. 396653-34-2
项目整合开发状态: Biological Testing
项目研究机构: CNRS (Originator)
合成路线:Alkylation of 2-amino-6-chloropurine (I) with 2-methoxybenzyl chloride (II) in the presence of K2CO3 and Bu4NI gives the 9-substituted purine (III).Amino purine (III) is converted into the corresponding 2-iodo derivative (IV) by treatment with isoamyl nitrite in hot diiodomethane.Finally,displacement of the 6-chloro group of (IV) with methylamine furnishes the desired adenine derivative.
📌 参考资料/链接：
参考文献标题:Design,synthesis and structure-activity relationships of a series of 9-substituted adenine derivatives as selective phosphodiesterase type-4 inhibitors
文献作者:Raboisson,P.; Lugnier,C.; Muller,C.; Reimund,J.-M.; Schultz,D.; Pinna,G.; Le Bec,A.; Basaran,H.; Desaubry,L.; Gaudiot,F.; Seloum,M.; Bourguignon,J.-J.
参考来源:Eur J Med Chem 2003,38(2),199