ML-3176

Chemical Name: 1-[2-[4-(Carboxymethyl)phenoxy]ethyl]-3-(1-dodecanoyl)-1H-indole-2-carboxylic acid
CAS No. 192182-47-1
项目整合开发状态: Preclinical
项目研究机构: Merckle (Originator)
合成路线:The condensation of ethyl indole-2-carboxylate (I) with dodecanoic acid (II) in the presence of polyphosphoric acid and trifluoroacetic anhydride produced the corresponding 3-dodecanoylindole (III).Subsequent alkylation of (III) with ethyl 4-(2-bromoethoxy)phenylacetate (IV) using potassium tert-butoxide in DMSO afforded the N-alkylated indole (V).The ethyl ester groups of (V) were finally hydrolyzed with KOH to provide the target diacid compound.