新产品编号:565283

Chemical Name: (-)-(3S,4S,6R,11S,11Sa)-4-Azido-11-bromo-11-methyl-3,6-epoxyperhydropyrimido[6,1-b][1,3]oxacine-8,10-dione; 3'-Azido-5(S)-bromo-3'-deoxy-6(S)-hydroxy-5',6-anhydrothymidine
CAS No. 224797-38-0
项目整合开发状态: Biological Testing
项目研究机构: Universidad de Buenos Aires (Originator), Universidad Nacional de C髍doba (Originator)
合成路线:By bromination of zidovudine (AZT) (I) with N-bromosuccinimide (NBS) in DMF through the nonisolated intermediate (II),which yields a diastereomeric mixture of the target (S,S) isomer along with some (R,R) isomer that have been separated by crystallization and preparative radial chromatography.