新产品编号:532061

Chemical Name: N-[2-(1-Benzyl-4-piperidinyl)ethyl]-6-phenylpyridazin-3-amine dihydrochloride hydrate
CAS No. 221196-21-0 (anhydrous), 221196-76-5 (free base)
项目整合开发状态: Biological Testing
项目研究机构: Universit?Louis Pasteur (Originator)
合成路线:Horner-Emmons reaction of 1-benzyl-4-piperidone (I) with diethyl cyanomethylphosphonate (II) in the presence of K2CO3 provided the piperidinilydeneacetonitrile (III).Reduction of the double bond of (III) with magnesium in MeOH yielded the saturated nitrile (IV),which was further reduced to amine (V) using LiAlH4.Treatment of 6-phenyl-3-pyridazinone (VI) with POCl3 gave the chloropyridazine (VII).This was coupled with diamine (V) in the presence of ammonium chloride in refluxing butanol to furnish the title pyridazinamine,which was finally converted to the dihydrochloride salt.