新产品编号:233063
Chemical Name: 1-Benzyl-3-(benzyloxymethyl)-3,4-dihydro-1H-1,3-benzothiadiazin-4-one S,S-dioxide
CAS No. 190835-51-9
项目整合开发状态: Biological Testing
项目研究机构: CSIC (Originator), Rega Institute for Medical Research (Originator)
合成路线:Benzothiadiazine dioxide (II) was prepared by cyclization of methyl anthranylate (I) with sulfamoyl chloride,followed by aqueous NaOH.After silylation of (II) by means of hexamethyldisilazane,alkylation with benzyloxymethyl acetate (III) in the presence of boron trifluoride etherate produced the 3-(benzyloxymethyl)benzothiazine (IV).Further alkylation of (IV) with benzyl bromide in aqueous NaHCO3 furnished the title compound.
📌 参考资料/链接：
参考文献标题:Novel potential agents for human cytomegalovirus infection: Synthesis and antiviral activity evaluation of benzothiadiazine dioxide acyclonucleosides
文献作者:Martinez,A.; Esteban,A.I.; Castro,A.; Gil,C.; Conde,S.; Andrei,G.; Snoeck,R.; Balzarini,J.; De Clercq,E.
参考来源:J Med Chem 1999,42(7),1145
📄 详细内容
合成路线:Benzothiadiazine dioxide (II) was prepared by cyclization of methyl anthranylate (I) with sulfamoyl chloride,followed by aqueous NaOH.After silylation of (II) by means of hexamethyldisilazane,alkylation with benzyloxymethyl acetate (III) in the presence of boron trifluoride etherate produced the 3-(benzyloxymethyl)benzothiazine (IV).Further alkylation of (IV) with benzyl bromide in aqueous NaHCO3 furnished the title compound.
参考文献标题:Benzothiadiazine dioxide acyclonucleosides as lead compounds for the development of new agents against human cytomegalovirus and varicella-zoster virus infection
文献作者:Esteban,A.I.; Martinez,A.; De Clercq,E.
参考来源:Bioorg Med Chem Lett 1997,7(8),1031