新产品编号:546299
Chemical Name: 2-Thioxo-1,2,3,4-tetrahydroimidazo[1,5-a]pyrimidine-8-carbothioamide
CAS No. 222292-68-4
项目整合开发状态: Biological Testing
项目研究机构: Minophagen (Originator)
合成路线:The reaction of 5-amino-1H-imidazole-4-carboxamide (I) with acryloyl chloride (II) by means of Et3N or K2CO3 in acetonitrile gives the intermediate,not isolated compound (III),which cyclizes to the imidazopyrimidine (IV).Finally,this compound is treated with Lawesson's reagent in dioxane or xylene.
合成路线:The reaction of 5-amino-1H-imidazole-4-carboxamide (I) with acryloyl bis-succinimide derivative (II) by means of Et3N or K2CO3 in acetonitrile gives the intermediate,not isolated compound (III),which cyclizes to the imidazo-pyrimidine (IV).Finally,this compound is treated with Lawesson's reagent in dioxane or xylene.
📌 参考资料/链接：
参考文献标题:Novel imidazo[1,5-a]pyrimidine derivs.and their preparation
文献作者:Mizuno,Y.; Matsumoto,K.; Nagata,N.(Minophagen Pharmaceutical Co.,Ltd.)
参考来源:JP 1999092478
📄 详细内容
合成路线:The reaction of 5-amino-1H-imidazole-4-carboxamide (I) with acryloyl chloride (II) by means of Et3N or K2CO3 in acetonitrile gives the intermediate,not isolated compound (III),which cyclizes to the imidazopyrimidine (IV).Finally,this compound is treated with Lawesson's reagent in dioxane or xylene.
合成路线:The reaction of 5-amino-1H-imidazole-4-carboxamide (I) with acryloyl bis-succinimide derivative (II) by means of Et3N or K2CO3 in acetonitrile gives the intermediate,not isolated compound (III),which cyclizes to the imidazo-pyrimidine (IV).Finally,this compound is treated with Lawesson's reagent in dioxane or xylene.
参考文献标题:Synthesis of 2,8-disubstituted imidazo[1,5-a]pyrimidines with potent antitumor activity
文献作者:Matsumoto,H.; Ikeda,K.; Nagata,N.; Takayanagi,H.; Mizuno,Y.; Tanaka,M.; Sasaki,T.
参考来源:J Med Chem 1999,42(9),1661