SB-268091
Chemical Name: (3aS,4R,5S,6S,8R,9R,9aR,10R)-2-(Quinuclidin-4-ylsulfanyl)acetic acid 5-hydroxy-4,6,9,10-tetramethyl-1-oxo-6-vinyldecahydro-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester
CAS No. 224296-26-8, 224296-27-9 (monohydrochloride)
项目整合开发状态: Preclinical
项目研究机构: GlaxoSmithKline (Originator)
合成路线:Treatment of pleuromutilin (I) with p-toluenesulfonyl chloride in pyridine at low temperature provided mutilin 14-(p-toluenesulfonyloxy)acetate (II).Subsequent condensation with quinuclidin-4-thiol hydrobromide (III) in the presence of NaOEt yielded the title sulfide.
合成路线:By condensation of mesylate (IV) with quinuclidin-4-thiol hydrochloride (V) in the presence of NaOMe.
📌 参考资料/链接：
参考文献标题:Pleuromutilin derivs.as antimicrobials
文献作者:Dabbs,S.; Hunt,E.; Berry,V.; Woodnutt,G.; Sanderson,F.D.; Frydrych,C.H.(SmithKline Beecham Corp.; SmithKline Beecham plc)
参考来源:EP 1028961; WO 9921855
📄 详细内容
合成路线:Treatment of pleuromutilin (I) with p-toluenesulfonyl chloride in pyridine at low temperature provided mutilin 14-(p-toluenesulfonyloxy)acetate (II).Subsequent condensation with quinuclidin-4-thiol hydrobromide (III) in the presence of NaOEt yielded the title sulfide.
参考文献标题:
文献作者:Zhu,C.F.; et al.
参考来源:J Antibiot 1976,29(2),132