N1-Phenethylnorcymserine

Chemical Name: N-(4-Isopropylphenyl)carbamic acid (3aS,8aR)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl ester
CAS No. 219920-69-1
项目整合开发状态: Preclinical
项目研究机构: Axonyx (Originator), National Institute on Aging (Codevelopment)
合成路线:The reaction of methiodide (I) with 2-phenylethylamine (II) gives N1-phenethylnoresermethole (III),which is demethylated with BBr3 yielding N1-phenethylnoreseroline (IV).Finally,this compound is condensed with 4-isopropylphenyl isocyante (V) to afford the target carbamate.