3-Allyl farnesol, 3-alFOH
Chemical Name: (2Z,6E)-7,11-Dimethyl-3-(2-propenyl)-2,6,10-dodecatrien-1-ol
CAS No. 247942-40-1
项目整合开发状态: Biological Testing
项目研究机构: Karmanos Cancer Institute (Originator), Purdue University (Originator), Wayne State University (Originator)
合成路线:Palladium-catalyzed coupling between the known vinyl triflate (I) and allyl tributyltin (II) provides adduct (III).Then,reduction of the ester function of (III) by means of DIBAL in cold toluene leads to the target allylic alcohol.
📌 参考资料/链接:
参考文献标题:Novel farnesol and geranylgeraniol analogues: A potential new class of anticancer agents directed against protein prenylation
文献作者:Gibbs,B.S.; Zahn,T.J.; Mu,Y.; Sebolt-Leopold,J.S.; Gibbs,R.A.
参考来源:J Med Chem 1999,42(19),3800